llya Ruvinsky

I am broadly interested in the evolution of development (Evo-Devo), evolutionary genomics and molecular evolution. The goal of the lab is to integrate developmental, genomic and computational approaches to understand the evolution of genes and gene functions. Although it is thought that morphological differences between species are often caused by changes in regulatory DNA sequences, relatively little is known about their evolution. We are working to fill this gap by investigating the pattern and functional consequences of cis- and trans-regulatory evolution.

I am broadly interested in the evolution of development (Evo-Devo), evolutionary genomics and molecular evolution. The goal of the lab is to integrate developmental, genomic and computational approaches to understand the evolution of genes and gene functions. Although it is thought that morphological differences between species are often caused by changes in regulatory DNA sequences, relatively little is known about their evolution. We are working to fill this gap by investigating the pattern and functional consequences of cis- and trans-regulatory evolution.

Wang P. P.-S. and Ruvinsky I. (2009). Computational prediction of Caenorhabditis box H/ACA snoRNAs using genomic properties of their host genes. RNA In press. 

Barrière A., Yang S.-P., Pekarek E., Thomas C. G., Haag E. S. and Ruvinsky I. (2009). Detecting heterozygosity in shotgun genome assemblies: Lessons from obligately outcrossing nematodes. Genome Res. 19: 470-480. 

Ruvinsky I., Ohler U., Burge C. B. and Ruvkun G. (2007). Detection of broadly expressed neuronal genes in C. elegans. Dev. Biol. 302: 617-626. 

Ruvinsky I. and Ruvkun G. (2003). Functional tests of enhancer conservation between distantly related species. Development 130: 5133-5142. 

Wang P. P.-S. and Ruvinsky I. (2009). Computational prediction of Caenorhabditis box H/ACA snoRNAs using genomic properties of their host genes. RNA In press. 

Barrière A., Yang S.-P., Pekarek E., Thomas C. G., Haag E. S. and Ruvinsky I. (2009). Detecting heterozygosity in shotgun genome assemblies: Lessons from obligately outcrossing nematodes. Genome Res. 19: 470-480. 

Ruvinsky I., Ohler U., Burge C. B. and Ruvkun G. (2007). Detection of broadly expressed neuronal genes in C. elegans. Dev. Biol. 302: 617-626. 

Ruvinsky I. and Ruvkun G. (2003). Functional tests of enhancer conservation between distantly related species. Development 130: 5133-5142.