Abraham A Palmer

Research Summary / Selected Publications

Genetic variation contributes to individual differences in the risk for a variety of psychiatric and other common diseases. For the common psychiatric diseases, multiple genes work in concert to confer risk, and interact with one another, as well as the environment, to determine the observed phenotype. Identifying these genes, as well as understanding their complex interactions, promises to revolutionize the diagnosis and treatment of psychiatric diseases. Our research uses mice as a model genetic system to identify specific genes that contribute to heritable disorders

Genetic determinants of sensitivity to methamphetamine (MA) in mice and humans. Individual differences in the sensitivity to drugs of abuse are controlled by both genetic and environmental factors. The genetic variants associated with differential sensitivity to abused drugs may partially underlie genetic liability for drug abuse. We have integrated QTL mapping with gene expression analysis and used these two approaches to identify genes that are associated with differential sensitivity to MA. Preliminary work with Harriet de Wit (Psychiatry) has established that at least one of these genes also regulates sensitivity to MA in human subjects who were administered MA in a controlled laboratory setting.

Translational genetic approach...

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Velez L, Sokoloff G, Miczek KA, Palmer AA, Dulawa SC. Differences in aggressive behavior and DNA copy number variants between BALB/cJ and BALB/cByJ substrains. Behav Genet, in press.

McCloskey M, Palmer AA, de Wit H. Is self-reported liking of d-amphetamine related to impulsivity? Psychopharmacology, in press.

Hamidovic A, Dlugos A, Palmer AA, de Wit H. Association between polymorphism in human dopamine D2 receptor and behavioral inhibition - a pharmacogenetic study with acute d-amphetamine administration. Exp Clin Psychopharmacol, in press.

Heydemann A, Ceco E, Lim JE, Hadhazy M, Ryder P, Moran JL, Beier DR, Palmer AA, McNally EM. Latent transforming growth factor binding protein 4 modifies muscular dystrophy, J Clin Invest, in press.

Bryant CD, Chang HP, Zhang J, Tarantino LM, Palmer AA. A major QTL on chromosome 11 influences psychostimulant and opioid sensitivity in mice. Genes, Brain Behav, 2009

Dlugos AM, Hamidovic A, Hodgkinson CA, Goldman D, Palmer AA, de Wit H. More aroused, less fatigued: FAAH gene polymorphisms influence acute response to amphetamine. Neuropsychopharm, in press

Dlugos AM, Badner J, Palmer AA, de Wit H. Negative emotionality: monoamine oxidase B gene variants modulate personality traits in healthy humans. J Neural Transm, 2009, 116:323

Dlugos AM, Hamidovic A, Skol AD, Palmer AA, de Wit H. Further evidence of association between amphetamine response and SLC6A2 gene variants. Psychopharmacology, 2009, 206:501

Dlugos AM, Hamidovic A, Hodgkinson CA, Goldman P, Shen D, Palmer AA, de Wit H. OPRM1 gene variants modulate amphetamine-induced euphoria in humans. The Pharmacogenomics Journal, in press.

Aldinger K, Sokoloff G, Rosenberg D, Palmer AA, Millen K. Genetic variation and population substructure in outbred CD-1 mice: implications for genome-wide association studies. PLoS One, 2009,4:e4729

Williams R, Lim JE, Harr B, Wing C, Walters R, Distler MG, Meike T, Wu C, Wiltshire T, Su AI, Sokoloff G, Tarantino LM, Borevitz JO, Palmer AA. A common and unstable copy number variant is associated with differences in Glo1 expression and anxiety-like behavior. PLoS One, 2009, 4:e4649

Bryant C, Graham M, Distler M, Munoz M, Li D, Vezina P, Sokoloff G, Palmer AA. Role for casein kinase 1 epsilon in the locomotor stimulant response to methamphetamine. Psychopharmacology, 2009, 203:703

Ponder CA, Huded CP, Munoz MB, Gulden FO, Gilliam TC, Palmer AA. Rapid selection response for contextual fear conditioning in a cross between C57BL/6J and A/J: behavioral, QTL and gene expression analysis. Behav Genet, 2008, 38:277-91. PDF Ponder et al 2008

Bryant CD, Zhang NN, Sokoloff G, Fanselow MS, Ennes HS, Palmer AA, McRoberts JA. Behavioral differences among C57BL/6 substrains: Implications for transgenic and knockout studies. Journal of Neurogenetics, 2008, 22(4):315-331.PDF Bryant et al 2008

Palmer AA, Brown, AS, Klugewicz D, DeSanti L, Rotrosen J, Butler PD Prenatal Protein Deprivation Alters Dopamine-Mediated Behaviors and Dopaminergic and Glutamatergic Receptor Binding. Brain Res. 2008 Oct 27;1237:62-74. Epub 2008 Jul 30.PDF Brown et al 2008

Velez L, Sokoloff G, Miczek KA, Palmer AA, Dulawa SC. Differences in aggressive behavior and DNA copy number variants between BALB/cJ and BALB/cByJ substrains. Behav Genet, in press.

McCloskey M, Palmer AA, de Wit H. Is self-reported liking of d-amphetamine related to impulsivity? Psychopharmacology, in press.

Hamidovic A, Dlugos A, Palmer AA, de Wit H. Association between polymorphism in human dopamine D2 receptor and behavioral inhibition - a pharmacogenetic study with acute d-amphetamine administration. Exp Clin Psychopharmacol, in press.

Heydemann A, Ceco E, Lim JE, Hadhazy M, Ryder P, Moran JL, Beier DR, Palmer AA, McNally EM. Latent transforming growth factor binding protein 4 modifies muscular dystrophy, J Clin Invest, in press.

Bryant CD, Chang HP, Zhang J, Tarantino LM, Palmer AA. A major QTL on chromosome 11 influences psychostimulant and opioid sensitivity in mice. Genes, Brain Behav, 2009

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Assistant Professor, Human Genetics, Committee on Genetics, Genomics & Systems Biology, Committee on Neurobiology

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Abraham A Palmer

Research Summary / Selected Publications