Molly Przeworski
Research Summary / Selected Publications
Genetic variation among extant individuals carries information about the evolutionary and genetic forces that have affected their ancestors. We are interested in leveraging this information to learn about the biology of humans and other species. Currently, the main foci of the group are to elucidate the human recombination process and the role of natural selection in shaping genetic variation. To this end, we combine modeling and data analysis, often working closely with experimentalists.
Genetic variation among extant individuals carries information about the evolutionary and genetic forces that have affected their ancestors. We are interested in leveraging this information to learn about the biology of humans and other species. Currently, the main foci of the group are to elucidate the human recombination process and the role of natural selection in shaping genetic variation. To this end, we combine modeling and data analysis, often working closely with experimentalists.
Fledel-Alon A, Wilson DJ, Broman K, Wen X, Ober C, Coop G and Przeworski M. (2009) Broad-scale recombination patterns underlying proper disjunction in humans. PLoS Genetics 5: e1000658.
Coop, G., Wen, W., Ober, C., Pritchard, J. K., and Przeworski, M. (2008) High resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans. Science 319: 1395-8.
Becquet, C., and Przeworski, M. (2007). A new approach to estimate parameters of speciation models, with application to apes. Genome Research 17: 1505-19.
Coop, G., and Przeworski, M. (2007). An evolutionary view of human recombination. Nature Reviews Genetics 8: 23-34.
Teshima KM, Coop G, Przeworski M. (2006) How reliable are empirical genomic scans for selective sweeps? Genome Research 16: 702-12.
Przeworski, M., Coop, G., and Wall, J. D. (2005). The signature of positive selection on standing genetic variation. Evolution 59: 2312-23.
Fledel-Alon A, Wilson DJ, Broman K, Wen X, Ober C, Coop G and Przeworski M. (2009) Broad-scale recombination patterns underlying proper disjunction in humans. PLoS Genetics 5: e1000658.
Coop, G., Wen, W., Ober, C., Pritchard, J. K., and Przeworski, M. (2008) High resolution mapping of crossovers reveals extensive variation in fine-scale recombination patterns among humans. Science 319: 1395-8.
Becquet, C., and Przeworski, M. (2007). A new approach to estimate parameters of speciation models, with application to apes. Genome Research 17: 1505-19.
Coop, G., and Przeworski, M. (2007). An evolutionary view of human recombination. Nature Reviews Genetics 8: 23-34.
Teshima KM, Coop G, Przeworski M. (2006) How reliable are empirical genomic scans for selective sweeps? Genome Research 16: 702-12.
