Joy Bergelson
Research Summary / Selected Publications
The research in my laboratory focuses on the ecology and evolution of plant resistance and pathogen virulence. Our approach is to combine ecological field experiments with transgenic manipulations in order to explore the fitness effects and selective histories of particular resistance genes. Recent work attempts to understand the evolutionary dynamics of the R-genes of Arabidopsis thaliana that are involved in gene-for-gene interactions with bacterial pathogens, and to determine the pleiotropic fitness effects of resistance. We have simultaneously been examining how plant resistance affects bacterial communities living in and on Arabidopsis, and how a selection acts on pathogenicity in these bacteria. A secondary focus is on patterns of polymorphism in Arabidopsis, and the development of markers for linkage disequilibrium mapping in this species.
The research in my laboratory focuses on the ecology and evolution of plant resistance and pathogen virulence. Our approach is to combine ecological field experiments with transgenic manipulations in order to explore the fitness effects and selective histories of particular resistance genes. Recent work attempts to understand the evolutionary dynamics of the R-genes of Arabidopsis thaliana that are involved in gene-for-gene interactions with bacterial pathogens, and to determine the pleiotropic fitness effects of resistance. We have simultaneously been examining how plant resistance affects bacterial communities living in and on Arabidopsis, and how a selection acts on pathogenicity in these bacteria. A secondary focus is on patterns of polymorphism in Arabidopsis, and the development of markers for linkage disequilibrium mapping in this species.
Nordborg, M, Hu, T, Ishino, Y, Toomajian, C, Jhaveri, J, Bakker, E, Calabrese, Gladstone, J, Goyal R, P, Jakobsson, M, Jhaveri, J, Kim, S, Padhukasahasram, B, Plagnol, V, Rosenberg, N, Schultz, V, Stevens, C, Shah, C, Wall, J, Wang, J, Zheng, H, Zhao, K, Kreitman, M and J Bergelson. The genomic pattern of polymorphism in Arabidopsis thaliana. 2005. PLoS Biology 3(7):e196
Goss, EM, Kreitman, M and J Bergelson. 2005. Genetic diversity, recombination and cryptic clades in Pseudomonas viridiflava infecting natural populations of Arabidopsis thaliana. Genetics 169: 21-35
Wichmann, G and J Bergelson. 2004. avr genes of Xanthamonas axonopodis pv. vesicatoria promote transmission and enhance other fitness traits. Genetics 166: 693-706.
Korves, T and J Bergelson. 2004. A novel fitness cost of R-gene resistance in the presence of disease. The American Naturalist 163: 489-504.
Tian, D, Traw, MB, Chen J, Kreitman, M and J Bergelson. 2003. Pleiotropic fitness cost of Rpm1 resistance in Arabidopsis thaliana. Nature 423: 74-77.
Nordborg, M, Borevitz, JO, Bergelson, J, Berry, J, Chory, J, Hagenblad, J, Kreitman, K, Maloof, JN, Noyes, T, Oefner, PJ, Stahl, E and D Weigel. 2002. The extent of linkage disequilibrium in the highly selfing species, Arabidopsis thaliana. Nature Genetics 30(2): 190-3.
Bergelson, J, Kreitman, M, Stahl, EA and D Tian. 2001. Evolutionary dynamics of R-genes in plants. Science 292: 2281-2285.
Stahl, E, Dwyer, G, Mauricio, R, Kreitman, M, and J Bergelson. 1999. Dynamics of disease resistance polymorphism at the Rpm1 locus of Arabidopsis. Nature 400: 667-671.
Nordborg, M, Hu, T, Ishino, Y, Toomajian, C, Jhaveri, J, Bakker, E, Calabrese, Gladstone, J, Goyal R, P, Jakobsson, M, Jhaveri, J, Kim, S, Padhukasahasram, B, Plagnol, V, Rosenberg, N, Schultz, V, Stevens, C, Shah, C, Wall, J, Wang, J, Zheng, H, Zhao, K, Kreitman, M and J Bergelson. The genomic pattern of polymorphism in Arabidopsis thaliana. 2005. PLoS Biology 3(7):e196
Goss, EM, Kreitman, M and J Bergelson. 2005. Genetic diversity, recombination and cryptic clades in Pseudomonas viridiflava infecting natural populations of Arabidopsis thaliana. Genetics 169: 21-35
Wichmann, G and J Bergelson. 2004. avr genes of Xanthamonas axonopodis pv. vesicatoria promote transmission and enhance other fitness traits. Genetics 166: 693-706.
Korves, T and J Bergelson. 2004. A novel fitness cost of R-gene resistance in the presence of disease. The American Naturalist 163: 489-504.
Tian, D, Traw, MB, Chen J, Kreitman, M and J Bergelson. 2003. Pleiotropic fitness cost of Rpm1 resistance in Arabidopsis thaliana. Nature 423: 74-77.
