Mary Sara McPeek

Applications of probability and statistics to genetics and molecular biology. Case-control association testing with related individuals, multipoint linkage disequilibrium mapping, identification of polymorphisms that explain a linkage result, relationship inference, analysis of quantitative trait loci in a complex pedigree, analysis of recombination and interference.

Applications of probability and statistics to genetics and molecular biology. Case-control association testing with related individuals, multipoint linkage disequilibrium mapping, identification of polymorphisms that explain a linkage result, relationship inference, analysis of quantitative trait loci in a complex pedigree, analysis of recombination and interference.

Zhao, H., Speed, T., McPeek, M.S. "Statistical analysis of crossover interference using the chi-square model" (1995) Genetics vol. 139, pp. 1045-1056.  

McPeek, M. S. "Optimal allele-sharing statistics for genetic mapping using affected pedigree members" (1999) Genetic Epidemiology 16: 225-249. 

McPeek, M. S., Strahs, A. "Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping" (1999) American Journal of Human Genetics 65: 858-875. 

McPeek, M. S., Sun L. "Statistical tests for detection of misspecified relationships using genome screen data" (2000) American Journal of Human Genetics vol 66, pp. 1076-1094  

Abney M., Ober C., McPeek M. S. "Quantitative trait homozygosity and association mapping and empirical genome-wide significance in large complex pedigrees: fasting serum insulin level in the Hutterites" (2002) American Journal of Human Genetics vol 70, pp. 920-934  

Sun L., Cox N. J., McPeek M. S. "A statistical method for identification of polymorphisms that explain a linkage result" (2002) American Journal of Human Genetics vol 70, pp. 399-411  

Bourgain C., Hoffjan S., Nicolae R., Newman D., Steiner L., Walker K., Reynolds R., Ober C., McPeek M. S "Novel case-control test in a founder population identifies P-selectin as an atopy susceptibility locus" (2003) American Journal of Human Genetics vol 73, pp. 612-626 

McPeek M. S., Wu X., Ober C. "Best linear unbiased allele-frequency estimation in complex pedigrees" (2004) Biometrics, vol. 60, pp. 359-367  

Bourgain C., Abney M., Schneider D., Ober C., McPeek M. S. "Testing for Hardy-Weinberg in samples with related individuals" (2004) Genetics, vol. 168, pp. 2349-2361  

Zhang J., Schneider D., Ober C., McPeek M. S. "Multilocus linkage disequilibrium mapping by the decay of haplotype sharing with samples of related individuals" (2005) Genetic Epidemiology, vol. 29, pp. 128-140  

Zheng M., McPeek M. S. "Multipoint Linkage Disequilibrium Mapping with Haplotype Block Structure" (2007) American Journal of Human Genetics, vol. 80, pp. 112-125  

Thornton T., McPeek M. S. "Case-Control Association Testing with Related Individuals: A More Powerful Quasi-Likelihood Score Test" (2007) American Journal of Human Genetics, vol 81, pp. 321-337  

Zhao, H., Speed, T., McPeek, M.S. "Statistical analysis of crossover interference using the chi-square model" (1995) Genetics vol. 139, pp. 1045-1056.  

McPeek, M. S. "Optimal allele-sharing statistics for genetic mapping using affected pedigree members" (1999) Genetic Epidemiology 16: 225-249. 

McPeek, M. S., Strahs, A. "Assessment of linkage disequilibrium by the decay of haplotype sharing, with application to fine-scale genetic mapping" (1999) American Journal of Human Genetics 65: 858-875. 

McPeek, M. S., Sun L. "Statistical tests for detection of misspecified relationships using genome screen data" (2000) American Journal of Human Genetics vol 66, pp. 1076-1094  

Abney M., Ober C., McPeek M. S. "Quantitative trait homozygosity and association mapping and empirical genome-wide significance in large complex pedigrees: fasting serum insulin level in the Hutterites" (2002) American Journal of Human Genetics vol 70, pp. 920-934